Selisseo® is the only hydroxy-selenomethionine on the market that is able to fully deliver the benefits of organic selenium to an enhanced stress resistance and immunity, optimal growth, a better reproduction performance and a higher quality of the end products.
❏ Selisseo® consistently provides animals with 100% hydroxy- selenomethionine (OH-SeMet), a pure, readily available and active form of organic selenium.
❏ Selisseo® leads to higher selenium deposition in muscles thanks to higher SeMet transfer to the tissues.
❏ Thanks to its technological properties, Selisseo® is able to fully deliver the benefits of organic selenium to obtain an enhanced stress resistance and immunity, optimal growth, a better reproduction performance and a higher quality of end products.
✔ Selenium (Se) is an essential nutrient for life. Selenium (Se) has established requirement from 0.1-0.3 ppm to support basic functions.
Although inorganic Se sources are commonly used as feed supplements, recent research has clearly confirmed that organic Se sources. and specifically selenomethionine (SeMet) and hydroxy-selenomethionine (OH-SeMet) in particular, are much more efficiently utilized.
✔ Selisseo® is a unique source of OH-SeMet (EU registration 3b814). At the 2014 SPACE exhibition in France. Selisseo® received the highest 3-Star InnovSpace Award. This award recognizes new product innovation.
✔ Selisseo® is stable. It can withstand extreme feed processing conditions, including high temperatures and pressure.
✔ Selisseo® is safe and easy to use. Its consistent particle size without fines makes it safe and easy to mix in the feed, with low dust levels.
✔ Selisseo® is pure and reliable. It provides 100% active OH-SeMet batch after batch.
✔ Selisseo® is 100% efficient. It is highly bioavailable and fully absorbed by the animal.
The concept of organic Se is to provide Se in the form of selenomethionine (SeMet), the only Se species that can be both utilized for selenoprotein production and safely stored in the body to build up Se reserves. An animal can utilize its store of Se during times of increased oxidative stress, when the need for Se is higher. These Se storages are key to maximizing all the benefits of Se.
However, only 63% of the Seleno-Yeast (SY) of Se is in the form of SeMet – and this percentage can be quite variable.
On the other hand, Selisseo® provides 100% of Se as OH-SeMet, thus ensuring an optimal Se reserve and supporting the performance of animals.
Learn more about the composition of SY in this video below, which summarizes the findings of Hachemi et al., 2023.
❏ Fertility rate: +2.43% vs SS in aging breeders (1), +3.6%vs SY(2)
❏ Hatchability: +9.6% vs SS(1) in aging breeders,+2.1% vs SY(2)
❏ Antioxidant status: +15.7% GPx vs SS(3) thus leading to a greater robustness of day-old chicks
❏ Final body weight: Consistently improved compared to SS and SY, up to +70 gr/head depending on the slaughter age(4)
❏ FCR: Consistently improved compared to SS and SY, up to –3 points depending on the slaughter age(5)
❏ Mortality: -4.2% vs SS(6)
❏ Se deposition in the muscles: +329% vs SS(7) and +78.2% vs SY(5)
❏ Antioxidant status:
❏ GPx4: +103.7% vs SS and +83.7% vs SY(5)
❏ Selenoprotein: +115.1% vs SS and +52.7% vs SY(5)
❏ Slow down of the oxidation process: of meat, thereby prolonging shelf life (lower drip loss and better color stability)(8),(9)
❏ Egg production: +5.4 eggs/hen vs SS**(10,11,15) and +3.8 eggs/hen vs SY**(10,15)
❏ FCR:-5% vs SS and -2% vs SY**(11,15)
❏ The longevity and bone quality of laying hens: Tibia resistance: +55% vs SS and Seedor index: +18% vs SS(11)
❏ Se-enriched egg: +144.4% Se concentration in the egg vs SS(11) and +55.9% vs SY(10)
❏ Eggshell thickness: +2.6% vs SS(11) | Eggshell strength: +7.9% vs SS(11)
❏ Marketable eggs produced per hen:
❏ +2.6% vs SS and +2.1% vs SY(10). On a million-hen complex, this corresponds to 4.31 M and 2.03 M more eggs.
❏ -0.9% cracked and broken eggs vs SS and SY(15)
❏ Egg Haugh Units: +78%</span vs SS after 10 days of storage(12), +6.3% vs SS after 14 days and at 30°C(13)
❏ Nutritional properties: -2.7% SFA and + 1.24% PUFA vs NC(14)
All the results reported in this document are extracted from trials in which Selisseo® was compared with another source of selenium. They should be considered as examples to demonstrate the effect of Selisseo®.
(1) Zorzetto et al., 2021, Italian Journal of Animal Science, 20:1, 1749-1758
(2) Trial conducted in Turkey, 2014
(3) Trial conducted on the Nalanda Broiler Research Farm, India , 2015
(4) Field trial, USA, 2020
(5) Sun et al., 2021, Antioxidants, 10(10):1542
(6) Trial conducted in Ghent University, Belgium, 2017
(7) De Marco et al., 2021, Italian Journal of Animal Science, 20:1, 514-525
(8) Trial conducted in France on turkey meat, CERN, 2014
(9)Trial conducted in the Texas A&M University Poultry Research Farm, USA, 2015
(10)Trial conducted in the University of Georgia, USA, 2021
(11)Trial conducted in Paraiba Federal University, Brazil, 2017
(12)Trial conducted in Thailand, 2015
(13)Trial conducted in Spain, 2018
(14)Tufarelli et al., 2016, Biol Trace Elem Res, 171, 453–458
(15)Trial conducted in the Ankara University Veterinary Faculty, Turkey, 2022
* GPx: Glutathion peroxidase | SFA: Saturated Fatty Acid | PUFA: Polyunsaturated Fatty Acids
**Average values of different trials carried out in different countries with different broilers strains
❏ Improve sow fertility through a better ovarian follicular development, optimal ovulation, better fertilization, as well as better embryonic development and implantation.
❏ Improve boar fertility through a better motility and survival of the spermatozoa(1)
Feeding sows with Selisseo® (0.3 ppm) at the end of the gestation period and during lactation leads to:
❏ a better transfer of GPx and IgG in newborn piglets for a better start: : +91.6% GPx and +84.8% IgG vs SS(2)
❏ a better transfer of Se to piglets through milk for a better weaning:
❏ a higher Se content in the muscles of piglets at 21 days: +46% vs SS(2)
❏ a higher IL-10 concentration in the blood after an LPS challenge: +73.7% vs SS(2)
It is also around the time pigs are vaccinated against various diseases. Selisseo® fed piglets can withstand this phase more easily thanks to:
❏ A higher antioxidant status: +16% total antioxidant capacity in serum vs SS(3)
❏ A lower diarrhea occurrence: +30% vs SS(3)
❏ A greater immune response after exposure to an LPS challenge: + 101% IL-10, 3 hours after the injection (anti-inflammatory response)(4)
❏ Improved FCR: –2.3% vs SS(3)
Selisseo® significantly increases Se deposition in muscles, with a greater bioavailability compared to Se-Yeast (up to +62%).(5)
The supplementation with Selisseo® restores the coloration of pork meat under heat stress to the same level as that under thermoneutral conditions.(6)
All the results reported in this document are extracted from trials in which Selisseo® was compared with another source of selenium. They should be considered as examples to demonstrate the effect of Selisseo®.
(1) Surai et al., 2016, Animal Feed Science and Technology,211, 18-30
(2)Li et al., 2019, Biological trace element research, 1-9.
(3) Trial conducted in China, Sichuan Agricultural University, 2016
(4) Trial conducted in the Netherlands, Schothorst Institute, 2016
(5) Jlali et al., 2014, Journal of animal science, 92 (1), 182-188
(6)Liu et al.,2021, Antioxidants,10(10),1558
More data are available on request
❏ a higher Se content in heifers’ plasma: +13% at 2 weeks pre-calving &+16% at calving vs SS(2)
❏ a higher SeMet transfer: +99% Se in the form of SeMet in heifers’ plasma 3 weeks pre-calving vs SS(2)
❏ an increased Se status of newborn calves: +14% vs SS(3)
❏ an improved Se status of dairy cows: increased Se deposition in both the plasma (+125% vs SS) and milk (+22,8% vs SS)(1)
❏ a better antioxidant status: higher GPx activity (+46%) and T-AOC (+19,6% vs SS) (1)
❏ a lower somatic cell count: –11,5%(5)
❏ less of a drop in the milk yield under heat stress conditions: +9,3% vs SS(6)
❏ positive modulation of several oxidative stress biomarkers under heat stress conditions:
❏ an improved total antioxidant capacity (+20% vs SS)
❏ lower plasma H2O2 (-18,5% vs SS)
❏ lower plasma nitric oxide (-22,9% vs SS)
❏ a higher Se content in the blood: +41,9% vs SS(4)
❏ a higher Se content in the blood:+19,1% vs SY (69% SeMet)(4)
❏ a reduced muscle drip loss after 8 days of storage: -36% vs SS, -11% vs SY (7)
All the results reported in this document are extracted from trials in which Selisseo® was compared with another source of selenium. They should be considered as examples to demonstrate the effect of Selisseo®.
(1)Sun et al., 2017, Journal of Dairy Science. 100(12), 9602-9610
(2)Trial conducted in UK, University if Reading, 2019
(3)Juniper et al., 2019, Journal of dairy science, 102(8), 7000-7010
(4) Field Trial conducted in France, 2018 (Dumont et al., 2018 , 3R)
(5) Field trial conducted in Egypt, Kassem Dairy Farm, 2017
(6) Sun et al., 2019, Journal of Dairy Science. 102(1), 311-319
(7) Grossi, Silvia et al., 2021, Antioxidants,10(4),596.
More data are available on request
The mineral selenium is essential for a wide range of biological processes in cattle including; growth, milk production, immunity and reproduction.
Any deficiency has a negative effect on the health and performance of cows due to a decline in antioxidant defences – often combined with stress. Cows can’t make selenium; it must come from their diet.
The form supplemented determines how much selenium is available to act as an antioxidant.
Selisseo® is a 100% pure source of hydroxy-selenomethionine, with a high level of bioavailability, backed up by science.
❏ Better antioxidant status: +50% GPx and +30%% SOD vs SY(3)
❏ Improved survival rate after stress: +5% vs NC(2), +4,5% vs SS(2), +2,2% vs SY(2)
❏ Improved average number of spawnings: +91% vs SS(4)
❏ Improved transfer of selenium to the progeny: +32% vs SS(4)
❏ Improved survival of the progeny (hatching to swim-up fry): +17% vs SS(4)
❏ Better reproductive performance: higher number and earlier female spawning(5)
❏ Higher Se deposition in the muscle: +125% vs NC and +80% vs SS (6)
❏ Higher selenoprotein and gene expression: +84% GPx, +50%CAT, +18% HSP 70 vs SS(6)
❏ Higher Se deposition in the Oocytes: +62% vs SS and in Swim-up fry: +53% vs SS(5)
❏ Total GPx enzymatic activity of the swim up fry: +70%vs NC and +18% vs SS(5)
❏ Higher biomass yield / tank: +10% vs negative control(1)
❏ Better antioxidant status: +10% GPx vs negative control(1) +7,5%SOD vs negative control(1)
❏ Improved survival rate under nitrite stress conditions: +20% vs negative control(1)
All the results reported in this document are extracted from trials in which Selisseo® was compared with another source of selenium. They should be considered as examples to demonstrate the effect of Selisseo®.
(1) Trial conducted in China, 2017 (Research Center)
(2) Trial conducted in Spain, University of Las Palmas, 2016
(3) Trial conducted in Spain, University of Las Palmas, 2017
(4) Trial conducted in Spain, University of Las Palmas, 2018
(5) Wischhusen et al., 2019, Aquaculture, 507, 126-138
(6) Mechlaoui et al, 2019. Aquaculture, 507, 251-259
Pierre-André GERAERT, past Marketing & Scientific Director of Adisseo, explains the genesis of Selisseo®, a pure form of organic selenium.
To obtain answers to these questions, listen to the explanations of Pierre-André!
Michele DE MARCO, Global Technical & Scientific support of Selisseo®, describes:
Michele explains how Selisseo® helps overcome oxidative stress.
To obtain answers to these questions, listen to the explanations of Anne Sophie Conjat, Global Business Manager of Selisseo® at Adisseo.
Garros Fontinhas, the South American Regional Business Coordinator, is talking about the different sources of selenium that are currently available to feed animals.
He explains the benefits of OH-SeMet (Selisseo®) in terms of absorption, deposition and the formation of selenoproteins.
A heat challenge?
Check the explanation of Garros to see how Selisseo® can alleviate the decrease in performance..
The only hydroxy-selenomethionine on the market, fully delivering:
It is the only hydroxy-selenomethionine on the market that is able to fully deliver the benefits of organic selenium.
It enables:
In general, eggs and meat are considered to be good sources of selenium in human diet.
The level and source of selenium present in poultry feed largely influences the selenium content in final consumable products.
Optimizing poultry nutrition is a solution to be considered to alleviate the potential nutrient deficiencies of food or increase its nutritional value.
Selisseo®, a pure form of organic selenium, is highly bioavailable and allows great selenium deposition in tissues.
After slaughtering, meat discoloration during storage may lead to consumer rejection, thus economical losses.
Meat color is influenced by a number of factors including ultimate pH, pigment content, myoglobin and oxidative status. A discoloration of meat frequently appears after 8 days storage.
Selisseo®, a pure organic selenium has shown to reduce the speed of discoloration and increase potential storage time.
Drip loss alters the perceived quality of meat in retail by the consumer. It also negatively impacts its juiciness and its conservation.
Research has revealed that drip loss is correlated with the oxidation of proteins in muscles. Proper supply of antioxidants through nutrition can contribute to reduce oxidation happening in chicken muscles.
Selisseo® is a pure organic selenium based antioxidant, which can help reducing protein oxidation and drip loss.
Birds are challenged all along the production cycle: hatching, transportation, high temperature, high density, diseases… These stresses affect performance and can result in increased mortality.
Mortality in broiler flocks represents lost income to growers and integrators. Improving the antioxidant capacity of animals through nutrition is a solution to be considered to reduce mortality in flocks.
Selisseo® is a pure organic selenium based antioxidant, with high potential for counteracting the negative effects of oxidative stress.
In animals 26 SeCys containing selenoproteins have been identified, all having essential functions, several of which directly detoxify oxidants. In chicken tissues selenium availability and stress are the main drivers for selenoprotein expression.
Selisseo, a pure form of organic selenium, provides adequate selenium levels for SeCys de novo synthesis and selenoprotein gene expression and activity.
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Selenium (Se) is an essential nutrient for life, with established requirement from 0.1 – 0.3 ppm to support basic functions. While inorganic Se is commonly used for feed supplements, recent research has firmly confirmed that organic Se, specifically selenomethionine (SeMet) or hydroxy-selenomethionine (OH-SeMet), is much easily integrated into body metabolism.
Selisseo® contains 100% hydroxy-selenomethionine, a pure and highly available form of organic selenium. Under oxidative stress situations, animals have the capacity to respond through enhanced production of selenoproteins, thus needing high supply of Selenocysteine (SeCys).
Selisseo® with its greater induction of SeCys synthesis is key to improve the ability of animals to whistand stressful physiological events such as birth or reproduction, but also challenged environment and health issues.
